Cape Girardeau, or simply “Cape” for locals, is a city along the Mississippi River. Its riverside location allows it to host a wide variety of flora and fauna, many of which you can find at Cape Girardeau Conservation Nature Center. Outdoor lovers can take on the nature trails there while keeping an eye out for local wildlife. Trail of Tears is another place to enjoy nature trails, but it also has historical significance as it pays tribute to the Cherokees who lost their lives when they were forced to cross the river. Child-friendly attractions can also be found in the area. Melaina’s Magical Playground provides a fun space for adults and children with disabilities to have fun.
These are only some of the spots that await you here. Scroll down for the top Airbnb vacation rentals in Cape Girardeau, Missouri, so you can be sure of having a comfortable place to stay during your trip.
We handpicked these listings carefully, considering (wherever possible) Superhost status, recent guest reviews, location, accommodation type, prices, availability of dates, decor, and amenities. The image galleries get refreshed with the latest updates regularly. They were last updated on April 14, 2024.
1. Romantic and historic guesthouse (from USD 102)
This guesthouse was built sometime in the 1800s, and the host has thoughtfully decorated the property to retain touches of its past, such as exposed brick walls. At the same time, the rental also features modern amenities such as WiFi and an HDTV.
This property is just right for two people, making this a great choice for couples. A claw foot tub adds a romantic touch to the property. Shops and restaurants are within walking distance of this home. Its location in the downtown area also makes it easy for you to explore the rest of what Cape Girardeau has to offer.
Top guest reviews
Amenities & Room:
beautiful cozy downtown cottage that feels like it’s in the woodsthe bathroom is very tiny but everything else is absolutely perfectthe carriage house is comfortable and so eclectically decoratedthis space is such a gem like they say i was comfortable and cozyCleanliness:
the guesthouse was adorable and clean with comfy furniturelaurie was great the place is in an awesome location and is very cleanHost:
laurie is super friendly and helpfulgreat restaurants nearby and laurie was super helpful pointing them all out including her favsRead more reviewsLocation:
perfect location to check out downtown capegreat location very fun little houselocation is perfect if you want to be downtowngreat location had everything we neededeasy walk to all of historic downtown cape and riverwalk
Superhost
2. Brickyard (from USD 145)
Brickyard is a beautiful Dutch Colonial Revival home that has been lovingly remodeled to retain vintage pieces while featuring modern furnishings. Feel free to tickle the ivories for your entertainment in the living area. Alternatively, you can watch TV or read one of the provided books during your downtime. You are also welcome to use the kitchen to prepare your own food and the laundry facilities if you want to get a clean set of clothes.
The house sits on a high bluff, providing you with views of two nearby parks.
Top guest reviews
Amenities & Room:
the air conditioning worked wonderfullythe air conditioning worked fantastic even in 100+ temp daysthe beds were very comfortable and the bathrooms are top notchour favorite room was the screened-in porchhowever this house has very nice new sinks washer and dryer bathrooms fridge dishwasher tvs etcCleanliness:
the basic essentials were provided and everything was clean and comfortableclean amazing shower and plenty of comfy cozy places to hang outthe beds were comfortable and bathrooms spaciousHost:
host was extremely responsivethe owners were nice and responsivebeautiful house and very nice ownerthe hosts were amazing - they really went above and beyondvery great host anything we needed and then someRead more reviewsLocation:
beautiful older house and good location close to downtownthe location is perfect for accessing everythingthe house is absolutely stunning and comfortable and in a great location
3. Lucky King (from USD 195)
Want to try your luck while at Cape Girardeau? This property puts you just across the street from a local casino. Despite the vibrant facility just steps away, you don’t need to worry about sleepless nights throughout your stay, as the area itself is quiet, allowing you to enjoy your rest.
The property has been remodeled to provide guests with glimpses of the city’s colorful history. It is well-equipped and includes a kitchen, laundry facilities, and a dedicated workspace among its amenities. On-site parking is available here, as well. Pets and infants are welcome here, so feel free to bring your whole family along.
Top guest reviews
Amenities & Room:
bedrooms were very comfy beds perfect large closet spaces and we fell in love with the kitchen and tablebeds were very comfortablethe house had 3 wonderful king beds which is nearly unheard of in most airbnb’sthe rooms were surprisingly large with large comfortable beds in each roombeds were so comfortableCleanliness:
it was very clean and comfortableit was beautiful and very cleanthe home was clean and as describedadorable cozy and clean housethe beds were super comfy fluffy pillows clean linens clean bathrooms and kitchenHost:
great host everything we needed for a weekend staywe had a really great stay the host was super responsive and helpfuloh my gosh this house and the host elizabeth is awesomeelizabeth was so helpful and always available to answer any questionsthanks elizabeth you were a magnificent host ’Read more reviewsLocation:
and the location was great right across the street from the casino
4. Log cabin with hot tub (from USD 128)
Forget about the idea that staying in a log cabin would be roughing it. Not only does this property come furnished with essentials, including a kitchen and laundry facilities, but it also comes with perks, including a private hot tub, a pool table, and darts equipment. In addition, you can step outside to hang out on the deck, sit around the fire pit, or play cornhole.
Staying here will make you feel as though you’re staying in the countryside, but the rental is actually just a short drive away from the downtown area.
Top guest reviews
Amenities & Room:
great stay love the deck and hot tub along with pool table very nicepool table was fun and even at 9° the hot tub was awesomethe beds are comfy and the backyard is beautifulthe bed is super comfycool cabin feel hot tub and pool table were funCleanliness:
clean cabin in a good areathe pool table and dart board were fun and the bed was clean and comfortablethe cabin was clean and has plenty of kitchen/cooking stuffcabin was great for a short honeymoon trip clean and convenient locationHost:
had everything we needed and more hosts exceptionally responsiveandrew was an excellent host he was very accommodating helpful and friendlywe had a lovely stay and hosts were very communicative and kindthank you for hosting us for the weekend -jc & krista mcpeakgreat restaurants and shops with friendly peopleRead more reviewsLocation:
cute little cabin on a quiet street just outside downtown so everything is closethis place is fun waiting to happenso close to the cool downtown area cool shops and restaurantsgreat place lots to do at this locationwonderful place it is a private area but so close to town
5. The Kage House (from USD 144)
The Kage House is a property dating back to the 1800s. This property is just minutes away from Main Street, where you can find shops and restaurants. Just across the street from the property is another restaurant that serves craft beers. If you prefer to cook your own food, the rental has its own kitchen equipped with modern appliances. You are also welcome to sit on the deck, where you can enjoy views of the Mississippi River.
On-site parking is available here. Do be aware that you will need to climb some steps to get to and from the property.
Top guest reviews
Amenities & Room:
a/c was outstanding as it was 100+ degrees outsidethe apartment is spacious with a full kitchen an updated bathroom and wifi that works greatthe kage house is a lovely apartment with all the amenities you could ask forthe apartment has a very cozy home vibe with a comfortable couch and bedlarge well-designed and well-furnished rooms totally up-to-date kitchen and bath great in-town location and a lovely river viewCleanliness:
clean spacious and comfortableit was clean finally a place that was up to our standards in cleanlinessit's very clean and i had lots of space and quietthe deck was so clean my white socks stayed cleangreat stay clean and comfy with a great viewHost:
the owner was awesomekeith was an awesome hostthe host was very responsive informative and thoughtfulkeith is a wonderful host responsive and generous to concernsand keith is one of the most responsive and supportive hosts i've ever hadRead more reviewsLocation:
perfect location within walking distance of downtown attractionsgreat location close by to local restaurants and bars within walking distancethe location was perfect for walking to great restaurants and exploring this cute towngreat location- walking distance to many shops and restaurantslocation is also a great asset
6. Family-friendly property in the Historic Boulevard District (from USD 90)
Check out this property if you’re looking for a family-friendly option. This rental is in a quiet neighborhood. It is furnished with amenities such as a crib, a high chair, and baby safety gates, as well as some toys and children’s dinnerware, for guests traveling with infants. The unit also has its own kitchen and laundry facilities.
Do note that this property is on the second floor, which you can access by climbing stairs. The rental is well-located and puts you within walking distance of the downtown area and the riverfront.
Top guest reviews
Amenities & Room:
each room was well appointed with comfortable furniture and decora/ c is easy to adjust tv and streaming works greatkitchen snacks are a nice touch and the kids enjoyed themloved the fans in each bedroomvery nice space comphy bed everything you could need charming decorCleanliness:
it was clean and comfortableit is clean and i loved the decorthe apartment is clean and very well appointedthe property was extremely clean and very invitinglocation is great always clean plenty of towels pillows blankets etcHost:
excellent hosts highly recommendedfrank and gail were great hostshosts are super responsive & helpfulgail was very friendly and quick to answer any questions i hadfrank and gail went above and beyond as hosts we enjoyed meeting frank and chatting with himRead more reviewsLocation:
easy parking and convenient location to great restaurantsperfect location for easy access to the spots we wanted to visitclose to downtown & easy to get anywhere in the citygreat location super cute space and comfy king bedthis is such a cute comfortable place to stay
7. Cozy cottage close to major attractions (from USD 124)
This cozy cottage is just right for a single family. It is well-appointed and includes all the amenities that you may need for short- and long-term stays, including a kitchen and laundry equipment. Linens and towels are also provided for your convenience. In addition, the home has a yard with a grill if you want to have a barbecue.
Free parking is available on the driveway or along the street. Moreover, this rental gives you easy access to local attractions, including Trail of Tears and the casino. Restaurants and wineries are close by, as well.
Top guest reviews
Amenities & Room:
great place to stay christina’s place was well-furnished in the kitchen bathroom and bedroomsthe bathroom update is adorable and functionalCleanliness:
very clean and neatthe home is very clean and the neighborhood felt safethe home was clean and in good orderHost:
responsive host and a comfortable space to visit my sister at semoRead more reviewsLocation:
highly recommend cute house with comfy beds in a great location very close to semowonderful place to stay centrally located to numerous restaurantsgreat location and easy to get everywhere we needed to goit was close to the college so i was comfortable making my way around town
8. Homey and spacious property with game room (from USD 181)
All you need to bring with you on your trip are yourself and your clothes if you stay in this property, as it is equipped with all the essentials. Besides the basics such as a kitchen, air-conditioning, and internet connection, this property also includes a game room for your leisure. Laundry and dishwasher pods, as well as toiletries, have also been provided so you don’t have to bring your own.
Towels and linens are provided by the host, as well. Additionally, rooms are equipped with darkening shades to help you get a good night’s rest.
Top guest reviews
Amenities & Room:
i love the fact that we could sit in the family room upstairs and enjoy watching tv togetherthere was plenty of space and it was very comfortablethe kitchen appliances and upstairs beds are niceCleanliness:
it was clean and the beds were amazingclean plenty of towels beds tvs and sitting spacethe space is clean and functionalit was clean and in a nice neighborhoodthis house was clean and very handy for our groupHost:
host was very accommodating and took care of all of our needsi would recommend this host for future staysthe home is well decorated and downright cozy the owner was great to work withms carla was a wonderful hostcarla was responsive and helpful for questions or concernsRead more reviewsLocation:
the house was centrally located in a quiet and very safe neighborhoodcomfortable stay quiet area close distance for dinning and shoppingthis was the perfect location for a weekend getaway with familyconvenient location and great communicationhouse was in a great location and we would definitely stay again
9. Historic home with river views (from USD 123)
This 1800s home features traces of its past in its furnishings, ceilings, and flooring. Appliances and furniture, however, have been updated for guests’ comfort. The kitchen is well-equipped and spacious so you can prepare your specialties with no issues.
Feel free to sit outside on the porch or take a nap in the hammock if the weather allows. The host also provides firewood if you want to use the fire pit. Enjoy views of the river from the second floor of this property and from the yard.
Top guest reviews
Cleanliness:
the house was clean and beautifully renovated with plenty of amenitiesgreat place great location quiet clean and well stockedHost:
amber was a great host and staying here was a very unique experience that was authentically cape girardeauRead more reviewsLocation:
an excellent stay close to downtown and a walking distance from the local farmers marketthis historic house definitely has that feel and was decorated so cute pretty well-equipped and great location
10. Dog-friendly property with balcony
Consider this option if you’re planning to bring your pup with you on your trip. This rental welcomes dogs, subject to an additional pet fee. The home comes with a balcony with seats if you want to sit outside. The interiors, meanwhile, include a kitchen and a dedicated workspace for your convenience. Toiletries, linens, and towels are thoughtfully provided by the host. A travel crib may also be made available if needed.
Each bedroom is equipped with a Smart TV so you don’t have to worry about fighting over the remote control.
Cape Girardeau, Missouri, United States
1.27 km (0.8 mi) from Capaha ParkAccommodates: 6
Top guest reviews
Amenities & Room:
king beds and tvs in every room was nicejeffrey’s apartment was perfect for our group of 4Cleanliness:
it was a nice clean spaceit was very clean and had a lot of charactervery nice little set up clean peaceful areacomfortable and clean would definitely stay againclean & modern throughout very comfortable beds two patiosHost:
jeffrey was very responsivejeffery was an amazing hosthe was very proactive and helpfulhe was ready to get a hold of and very attentivegreat place to stay awesome host and wonderful living space and great locationRead more reviewsLocation:
great location and easy to findsuper nice place in a nice location in towngreat location for visiting your semo studentwhat a perfect placegreat communication and great stay nice location for the area and had everything we needed
Experience the best of Cape Girardeau
Cape Girardeau is a great destination to head to if you want to bond with Mother Nature. However, you can also enjoy modern comforts and conveniences when you stay there. Choose from these rentals so you can guarantee yourself a comfortable place to lay your head after a day of sightseeing.
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